In 1970, a storage wing was added and followed by Specialty Clinics, Pathology, Pharmacy, and Dietary. This and other additions, including upgraded parking facilities, piped oxygen, a portable heart monitor and defibrillator, a second X-ray machine, an electronic computer for general accounting, and a two-bed coronary care unit, were all paid for from operating surpluses and donations. The ACH Board and medical staff added additional equipment and services to eliminate lengthy trips to distant cities for many diagnostic procedures.

The 1980s found increasing advances in technology and new government regulations being imposed on health care facilities. Some of the major new additions included in this renovation project were a state-of-the-art Emergency Department, operating suite, special care unit, a larger Outpatient Specialty Clinic area, Albert R. Hanna Care Center, office space, and a modernized Imaging Department, including X-Ray, Ultrasound, Nuclear Medicine, C.T., and Mammography equipment. In keeping with the trend toward outpatient services, the bed complement was reduced to 67 beds.

The late 1980s and early 1990s found ACH continuing to serve the residents in and around the county with efficient, high-quality health care. During these years, ACH HomeCare, Lyric Health Care Center, Sports Medicine, Occupational Health Care Center, Rehabilitation Center (including expanded physical therapy, occupational therapy, cardiac, pulmonary, stroke, and speech therapy services and fitness programs), ACH Medical Arts Center, and the Northern Adams Medical Center joined the family of health care services.

Groundbreaking for an additional/upgraded medical facility took place on July 29, 2005. The ground was donated on Moores Road, near Seaman, Ohio, after extensive research and a feasibility study determined the growth in the next ten years to be along the Appalachian Highway corridor, which connects Adams County to the Cincinnati area.

The upgraded facility, Adams County Regional Medical Center, opened its doors for the first patient on August 6, 2007. A Critical Access facility, ACRMC has 25 private inpatient units and 25 private outpatient units, 5 of which are designated as an inpatient Hospice Unit, collaborating with Hospice of Hope – Ohio Valley. The Emergency Department has 14 private examination rooms, with three being explicitly equipped for trauma. The Surgical Suite is comprised of two operating rooms and an endoscopy procedure room. The Imaging, Rehabilitation, Outpatient Specialty Clinic, Laboratory, and Cardiopulmonary Departments were enlarged to meet new technology demands and provide access to needed medical services to our area.

In 2015, Adams County Regional Medical Center faced financial hardship, and Rural Hospital Group, a rural hospital management company, took over the critical access hospital management.

In October 2019, Adams County Regional Medical Center transitioned to a 501c3 non-profit organization.
Adams County Regional Medical Center began to extend its medical coverage by opening a family medicine clinic in Winchester and later, West Union, Georgetown, and Mt. Orab.

Today, Adams County Regional Medical Center offers medical care at 5 locations with thirty specialty programs and departments.